Healthcare
We create and invest in leading companies in therapeutics, medtech, and health IT & services.
Twenty Eight products and drugs approved
With another 7 drugs in phase 3. Typically, only 1 in 5,000 drugs makes it from idea to market.
Twenty four companies created from scratch
If we can't find a company solving an important problem, we create one ourselves - just like we did with Innovent, Denali, and Beam to name a few.
Nearly two billion dollars over seven funds
Without the pressure of fundraising from outside investors, we're privileged to champion companies that help heal the world.
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Menlo Therapeutics Inc. (NASDAQ: MNLO) is a late stage biopharmaceutical company focused on the development and commercialization of serlopitant for the treatment of pruritus (itch) associated with dermatologic conditions such as atopic dermatitis, psoriasis and prurigo nodularis. Learn more at www.menlotherapeutics.com.
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Category
- Therapeutics
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Status
- Public
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Location
Menlo Park, CA
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Year Invested
2015
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Team
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Xilio Therapeutics is a biotechnology company advancing next-generation cancer immunotherapies designed to improve patient outcomes by unleashing the power of the immune system selectively at the site of the tumor. Learn more at www.xiliotx.com.
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Category
- Therapeutics
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Status
- Private
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Location
Waltham, MA
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Year Invested
2016
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Team
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Compass is comprehensively drugging the tumor-immune synapse with human antibodies against over 50 cell surface and soluble targets. Learn more at www.compasstherapeutics.com.
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Category
- Therapeutics
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Status
- Private
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Location
Cambridge, MA
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Year Invested
2015
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Team
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Orchard Therapeutics (NASDAQ:ORTX) Orchard Therapeutics is a fully integrated commercial-stage biopharmaceutical company dedicated to transforming the lives of patients with serious and life-threatening rare diseases through innovative gene therapies. Learn more at www.orchard-tx.com.
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Category
- Therapeutics
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Status
- Public
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Location
London, United Kingdom
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Year Invested
2016
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Team
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VitalWare makes the business of healthcare easier for providers through cloud-based SaaS solutions for analytics, documentation, coding, billing, and auditing technologies. VitalWare was acquired by Health Catalyst in 2020.
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Category
- Health IT/Services
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Status
- Acquired
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Location
Yakima, WA
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Year Invested
2015
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Team
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PatientPing is a care coordination platform that reduces the cost of healthcare by seamlessly connecting providers to coordinate patient care. Patient Ping was acquired by Appriss Health in 2021.
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Category
- Health IT/Services
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Status
- Acquired
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Location
Boston, MA
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Year Invested
2015
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Team
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Orient Speech Therapy Limited (“OST”) is a Hong-Kong based healthcare services provider that operates a chain of private speech therapy clinics in China. Learn more at www.dfqy.com.
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Category
- Health IT/Services
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Status
- Private
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Location
Hong Kong, China
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Year Invested
2015
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Team
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Medwell Ventures Private Unlimited (“Medwell”) is an operator of specialty home healthcare services in India. Learn more at www.medwellventures.com.
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Category
- Health IT/Services
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Status
- Private
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Location
Bangalore, India
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Year Invested
2015
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Team
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Denali Therapeutics (NASDAQ:DNLI) is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development. Learn more at www.denalitherapeutics.com.
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Category
- Therapeutics
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Status
- Public
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Location
San Francisco, CA
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Year Invested
2015
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Team
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Gu Sheng Tang (“GST”) is a Guangzhou, China-based healthcare services provider that operates a chain of private clinics specializing in traditional Chinese medicine. Learn more at www.gstzy.cn.
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Category
- Health IT/Services
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Status
- Private
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Location
Guangzhou, China
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Year Invested
2015
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Team
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Huan Qui Li Kang Technology Co., Ltd. (“HQ”) is an early stage hemostatic product manufacturer in China.
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Category
- MedTech
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Status
- Private
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Location
China
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Year Invested
2015
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Team
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Eyebright Medical Technology Co., Ltd. (SHA: 688050) is an emerging leader in the ophthalmologic device market in China. Learn more at www.ebmedical.com.
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Category
- MedTech
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Status
- Public
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Location
Beijing, China
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Year Invested
2015
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Team
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Zhejiang Bang Er Medical Investment Management Co., Ltd. is a leading private medical service provider that operates several private hospitals specializing in orthopedic care and related services in China. Learn more at www.zjbanger.com.
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Category
- Health IT/Services
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Status
- Private
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Location
Zhejiang, China
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Year Invested
2015
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Team
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Cygnus Hospitals is an asset-light chain of 10 hospitals based in North India, focusing on select higher-secondary and tertiary-care specialties. Learn more at www.cygnushospitals.com.
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Category
- Health IT/Services
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Status
- Private
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Location
Delhi, India
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Year Invested
2015
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Team
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Quartet Health is developing care coordination software and services designed to improve clinical outcomes and reduce the cost of care for patients where behavioral health is the primary or a comorbid condition. Learn more at www.quartethealth.com
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Category
- Health IT/Services
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Status
- Private
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Location
New York, NY
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Year Invested
2015
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Team
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Caribou (NASDAQ:CRBU) is a leading company in CRISPR genome editing founded by pioneers of CRISPR-Cas9 biology. Caribou’s proprietary technologies put the company at the forefront of the development of new medical therapies. Learn more at www.cariboubio.com.
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Category
- Therapeutics
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Status
- Public
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Location
Berkeley, CA
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Year Invested
2015
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Team
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Semma Therapeutics is a regenerative medicine company founded to develop transformative stem cell-derived therapies to provide a functional cure for patients with diabetes. This company was acquired by Vertex in 2019.
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Category
- Therapeutics
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Status
- Acquired
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Location
Cambridge, MA
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Year Invested
2014
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Team
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Stride Health is an early-stage healthcare IT company developing a multi-carrier, private health insurance marketplace for the individual segment. Learn more at www.stridehealth.com.
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Category
- FinTech
- Health IT/Services
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Status
- Private
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Location
San Francisco, CA
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Year Invested
2014
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Team
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TraceLink the world’s largest Track and Trace Network for connecting the life sciences supply chain and providing real-time information sharing for better patient outcomes. Learn more at www.tracelink.com.
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Category
- Health IT/Services
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Status
- Private
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Location
Wakefield, MA
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Year Invested
2015
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Team
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WellAir is a global company working to disinfect and purify indoor air for optimal human health and building performance. Learn more at www.wellairsolutions.com.
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Category
- Health IT/Services
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Status
- Private
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Location
Dublin, Ireland
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Year Invested
2014
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Team
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Surface Oncology (NASDAQ:SURF) is an immuno-oncology company developing next-generation antibody therapies focused on the tumor microenvironment with lead programs targeting CD73, CD39, IL-27 and CD47. Learn more at www.surfaceoncology.com.
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Category
- Therapeutics
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Status
- Public
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Location
Cambridge, MA
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Year Invested
2014
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Team
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Adaptimmune (NASDAQ: ADAP) is a cellular therapeutics company developing affinity enhanced T-cell receptor (TCR) engineered T-cells to treat solid tumor and hematological cancers. Learn more at www.adaptimmune.com.
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Category
- Therapeutics
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Status
- Public
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Location
Oxford, UK
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Year Invested
2014
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Team
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US HealthVest provides specialized, high quality psychiatric care, including substance abuse treatment, through a broad range of inpatient and outpatient programs. Learn more at www.ushealthvest.com.
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Category
- Health IT/Services
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Status
- Private
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Location
New York, NY
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Year Invested
2013
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Team
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Lumere (formerly Procured Health) is an organization comprised of clinicians, researchers, pharmacists and strategic thought leaders focused on helping health systems eliminate unwarranted clinical variation and cut unnecessary costs—specifically related to device and drug selection and utilization. This company was acquired by Global Healthcare Exchange (GHX) in 2020.
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Category
- Health IT/Services
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Status
- Acquired
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Location
Chicago, IL
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Year Invested
2012
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Team
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Liazon is a provider of web-based private benefits exchanges to small and medium-sized businesses. Liazon was acquired by Towers Watson in 2013. Learn more at www.liazon.com.
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Category
- Health IT/Services
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Status
- Acquired
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Location
Buffalo, NY
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Year Invested
2012
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Team
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Kyruus uses the science of data-driven clinical matching to ensure that patients are being matched to the right provider and enabling healthcare systems to coordinate care delivery across their provider networks. Learn more at www.kyruus.com.
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Category
- Health IT/Services
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Status
- Private
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Location
Boston, MA
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Year Invested
2012
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Team
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Iora Health is building a different kind of health system to deliver high impact, relationship based care. Iora Health was acquired by One Medical in September 2021.
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Category
- Health IT/Services
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Status
- Acquired
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Location
Cambridge, MA
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Year Invested
2011
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Team
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ViewRay (NASDAQ: VRAY) designs, manufactures and markets the MRIdian® radiation therapy system. Which uses a high-definition MR imaging system designed from the ground up to address the unique challenges and clinical workflow for advanced radiation oncology. Learn more at www.viewray.com.
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Category
- MedTech
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Status
- Public
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Location
Oakwood Village, OH
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Year Invested
2008
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Team
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Trivitron Healthcare is India’s largest, national wholesale distributor and after-sales support provider of medical equipment and devices. Learn more at www.trivitron.com.
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Category
- MedTech
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Status
- Private
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Location
Chennai, India
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Year Invested
2012
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Team
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TCT Medical is a diagnostic company based in China which provides high quality diagnostic tests, primarily in the women’s health arena. TCT Medical was acquired by Hologic.
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Category
- MedTech
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Status
- Acquired
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Location
Beijing, China
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Year Invested
2009
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Team
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MDDF is a medical device company focused on the manufacturing, development, and commercialization of high quality, affordably priced cardiovascular and general surgery medical devices for the Chinese market.
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Category
- MedTech
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Status
- Private
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Location
Beijing, China
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Year Invested
2011
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Team
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Ivenix is dedicated to eliminating infusion-related patient harm, uniquely positioned at the crossroads of healthcare IT and infusion delivery. Learn more at www.ivenix.com.
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Category
- MedTech
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Status
- Private
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Location
Amesbury, MA
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Year Invested
2011
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Team
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BioRegen Biomedical is a fully integrated medical product company based on a proprietary technology platform. BioRegen is developing and commercializing high quality hyaluronic acid (“HA”) based products for the Chinese market. Learn more at www.bioregenmed.com.
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Category
- MedTech
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Status
- Private
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Location
China
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Year Invested
2010
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Team
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BioConnect Systems was a medical device company that developed a CE-Marked product for improving dialysis access surgery. Learn more at www.bioconnectsystems.com.
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Category
- MedTech
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Status
- Private
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Location
Fort Washington, PA
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Year Invested
2007
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Team
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Better Life Medical is a fully-integrated hearing aid manufacturer developing and commercializing novel digital programmable hearing aid solutions for the Chinese market. Learn more at www.goblm.com.cn/.
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Category
- MedTech
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Status
- Private
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Location
Suzhou, China
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Year Invested
2011
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Team
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Amphora Medical was a medical device technology company developing minimally invasive products to restore the quality of life of people suffering from Overactive Bladder Syndrome.
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Category
- MedTech
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Status
- Acquired
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Location
Maple Grove, MN
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Year Invested
2013
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Team
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Accuri Cytometers was a life sciences tools company that democratized flow cytometry for medical and pharmaceutical research. Accuri Cytometers was acquired by Becton Dickinson.
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Category
- MedTech
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Status
- Acquired
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Location
Ann Arbor, MI
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Year Invested
2008
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Team
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Vicept Therapeutics is a dermatology specialty pharmaceutical company developing a topical prescription product for the treatment of the chronic skin condition, Rosacea. Vicept Therapeutics was acquired by Allergan.
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Category
- Therapeutics
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Status
- Acquired
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Location
Malvern, PA
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Year Invested
2009
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Team
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Ultragenyx (NASDAQ: RARE) a biopharmaceutical company committed to bringing to patients novel products for the treatment of serious rare and ultra-rare genetic diseases. Learn more at www.ultragenyx.com.
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Category
- Therapeutics
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Status
- Public
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Location
Novato, CA
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Year Invested
2011
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Team
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Transave is focused on improving the treatment of serious lung diseases through the company’s next generation, proprietary liposomal delivery technology.
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Category
- Therapeutics
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Status
- Public
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Location
Monmouth Junction, NJ
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Year Invested
2006
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Team
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Topaz Pharmaceuticals is a specialty pharmaceutical company developing a topical prescription product, Sklice, for the treatment of head lice. Topaz Pharmaceuticals was acquired by Sanofi.
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Category
- Therapeutics
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Status
- Acquired
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Location
Horsham, PA
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Year Invested
2007
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Team
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Tetraphase (NASDAQ: TTPH) is a biopharmaceutical company using its proprietary chemistry technology to create novel antibiotics for serious and life-threatening bacterial infections; its lead product XERAVATM (eravacycline) is approved for the treatment of complicated intra-abdominal infections by the FDA and EMA. Learn more at www.tphase.com.
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Category
- Therapeutics
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Status
- Public
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Location
Watertown, MA
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Year Invested
2006
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Team
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Symbiomix developed the first oral, single dose treatment in the United States for bacterial vaginosis (BV), a common gynecological infection that increases the risk of serious health problems. Symbiomix was acquired by Lupin Pharmaceuticals. Learn more at www.symbiomix.com.
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Category
- Therapeutics
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Status
- Acquired
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Location
Newark, NJ
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Year Invested
2013
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Team
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RespiVert was a drug discovery and development company focused on inhaled therapies for severe respiratory disease. RespiVert was acquired by Centocor Ortho Biotech – a division of Johnson & Johnson.
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Category
- Therapeutics
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Status
- Acquired
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Location
London, UK
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Year Invested
2007
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Team
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Pulmocide is a biopharmaceutical company with a mission to treat common acute and chronic respiratory tract infections associated with serious complications and devastating effects on patients’ quality of life. Learn more at www.pulmocide.com.
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Category
- Therapeutics
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Status
- Private
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Location
London, UK
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Year Invested
2013
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Team
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Proteostasis Therapeutics (NASDAQ: PTI) is a drug discovery company developing small molecule therapeutics to treat cystic fibrosis and other diseases caused by dysfunctional protein processing. Learn more at www.proteostasis.com.
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Category
- Therapeutics
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Status
- Public
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Location
Cambridge, MA
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Year Invested
2008
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Team
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NextWave Pharmaceuticals is a specialty pharmaceutical company seeking to create and promote differentiated products in the pediatric market. NextWave Pharmaceuticals was acquired by Pfizer.
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Category
- Therapeutics
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Status
- Acquired
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Location
Cupertino, CA
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Year Invested
2007
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Team
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Mersana Therapeutics (NASDAQ:MRSN) has its lead product candidate, XMT-1536, in clinical trials in patients with tumors expressing NaPi2b, including ovarian cancer, NSCLC, and other cancers. In addition, multiple partners are using Mersana’s platform to advance their ADC pipelines. Learn more at www.mersana.com.
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Category
- Therapeutics
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Status
- Public
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Location
Cambridge, MA
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Year Invested
2005
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Team
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LigoCyte Pharmaceuticals was a vaccine discovery and development company with a first-in-class vaccine for norovirus, a pathogen that is a leading cause of viral gastroenteritis (stomach flu). LigoCyte Pharmaceuticals was acquired by Takeda.
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Category
- Therapeutics
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Status
- Acquired
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Location
Bozeman, MT
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Year Invested
2008
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Team
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Laurus Labs (NSE:LAURUSLABS) is a leading manufacturer of Active Pharmaceutical Ingredients (API) for anti-retroviral (HIV-AIDS), oncology, nutraceutical and several other products, with a customer base that spans top-tier generic pharmaceutical companies in India and abroad. Learn more at www.lauruslabs.com.
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Category
- Therapeutics
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Status
- Public
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Location
Hyderabad, India
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Year Invested
2012
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Team
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Ironwood Pharmaceuticals (NASDAQ:IRWD) developed linaclotide, a first-in-class therapy that received FDA approval for both irritable bowel syndrome and chronic constipation. Learn more at www.ironwoodpharma.com.
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Category
- Therapeutics
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Status
- Public
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Location
Cambridge, MA
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Year Invested
2002
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Team
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Ikano Therapeutics is a specialty pharmaceutical company focused on developing Midazolam Nasal Spray (USL261) for acute repetitive seizures. Ikano was acquired by UCB.
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Category
- Therapeutics
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Status
- Acquired
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Location
Montvale, NJ
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Year Invested
2006
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Team
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Innovent Biologics (1801.HK) has built a robust pipeline of innovative and commercially promising monoclonal antibodies and other biologics in the fields of oncology, ophthalmology, autoimmune, and cardiovascular diseases. Learn more at www.innoventbio.com.
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Category
- Therapeutics
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Status
- Public
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Location
Suzhou, China
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Year Invested
2011
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Team
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Hua Medicine (2552.KHK) is a leading clinical-stage, innovative drug development company in China, focused on novel therapies for the treatment of diabetes and CNS disorders. Learn more at www.huamedicine.com.
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Category
- Therapeutics
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Status
- Public
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Location
Shanghai, China
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Year Invested
2010
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Team
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FoldRx Pharmaceuticals focuses on creating disease modifying drug therapies for diseases of protein misfolding. FoldRx developed, tafamidis, the first-in-class therapy approved or TTR amyloidosis. FoldRx was acquired by Pfizer.
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Category
- Therapeutics
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Status
- Acquired
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Location
Cambridge, MA
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Year Invested
2004
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Team
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Dimension Therapeutics was a leader in the development of AAV (adeno-associated virus) gene therapies for rare disease. Dimension Therapeutics was acquired by Ultragenyx Pharmaceuticals (NASDAQ:RARE).
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Category
- Therapeutics
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Status
- Acquired
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Location
Cambridge, MA
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Year Invested
2013
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Team
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CardioKine is a pharmaceutical company focused on the development of lixivaptan, an oral compound under development for the potential treatment of hyponatremia in patients with congestive heart failure. CardioKine was acquired by Cornerstone Therapeutics.
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Category
- Therapeutics
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Status
- Acquired
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Location
Philadelphia, PA
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Year Invested
2006
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Team
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Blueprint Medicines (NASDAQ: BPMC) is a precision therapy company striving to improve human health. Learn more at www.blueprintmedicines.com.
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Category
- Therapeutics
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Status
- Public
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Location
Cambridge, MA
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Year Invested
2012
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Team
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Bikam Pharmaceuticals is a drug discovery company focused on developing novel therapies for diseases of the eye with exceptionally high unmet medical need. Bikam Pharmaceuticals was acquired by Shire.
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Category
- Therapeutics
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Status
- Acquired
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Location
Cambridge, MA
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Year Invested
2007
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Team
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Adagene (Nasdaq: ADAG) is an antibody discovery and engineering company with proprietary Smart Antibody Technology, which increases success rates, substantially accelerates time to market, and reduces the costs associated with developing a therapeutic antibody. Learn more at www.adagene.com.
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Category
- Therapeutics
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Status
- Public
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Location
Suzhou, China
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Year Invested
2011
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Team
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Aclaris Therapeutics, Inc. (NASDAQ:ACRS) is a dermatologist-led biopharmaceutical company committed to identifying, developing and commercializing innovative therapies to address significant unmet needs in aesthetic and medical dermatology and immunodermatology. Learn more at www.aclaristx.com.
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Category
- Therapeutics
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Status
- Public
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Location
Malvern, PA
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Year Invested
2012
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Team
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Acacia Pharma (EURONEXT:ACPH) is a commercially driven hospital pharmaceutical group focused on the development and commercialisation of new nausea and vomiting treatments for surgical and cancer patients. Learn more at www.acaciapharma.com.
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Category
- Therapeutics
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Status
- Public
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Location
Cambridge, United Kingdom
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Year Invested
2013
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Team
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