R1 Therapeutics is a clinical-stage biopharmaceutical company focusing on the development of first-in-class therapies for patients with kidney disease. Its lead program, AP306, targets hyperphosphatemia in patients with chronic kidney disease on dialysis, a condition associated with serious bone and cardiovascular complications and poorer outcomes when phosphate remains uncontrolled. AP306 is a first-in-class pan phosphate active transporter inhibitor with the potential to deliver rapid and effective phosphate lowering with a significantly reduced treatment burden. R1 is advancing AP306 in a global Phase 2b development program.
Region: North America
Jump
Jump is an AI assistant for wealth management, enabling financial advisors to automate workflows prior to, during, and after client-facing meetings. Using Jump, advisors can save up to 20 hours per week by automating administrative tasks like meeting prep, note-taking, and email follow-up.
Alder
Alder offers expert, hands-on support for families navigating the complexities of aging. Alder is a team of experienced social workers and nurses helping families navigate the complexities of aging with compassion, clarity, and hands-on support.
Quarry Thera
Quarry Thera is a biotech company advancing next-generation proximity-induced therapeutics using molecular glues. Molecular glues represent a powerful new drug modality, leveraging proprietary DNA-encoded libraries, structure-based design, and advanced medicinal chemistry to overcome challenges like limited efficacy, poor permeability, and the difficulty of targeting undruggable proteins.
iRiva Medical
iRiva Medical is developing next-generation neuromodulation technology aimed at treating chronic diseases. The company focuses on addressing unmet clinical needs for large patient populations through innovative implantable medical devices.
Limitless.Exchange
Limitless.Exchange is a prediction market platform that makes trading crypto and stocks as simple as possible. Built on Base, Limitless offers short-term fast price markets that settle instantly with no liquidation risk or hidden fees. It enables users to trade on short-term predictions—such as whether Bitcoin, Ethereum, or major stock indices will rise above specific price thresholds within 30- or 60-minute markets—without liquidation risk or hidden fees.
Arnatar Therapeutics
Arnatar is reimagining RNA medicines to precisely silence disease drivers or restore what’s missing. Through their dual-modality DARGER™ platform, they develop best-in-class siRNA and first-in-class upregulating ASOs for cardiometabolic, liver, CNS, and kidney diseases.
Spinwheel
Spinwheel is revolutionizing the consumer credit ecosystem. The company partners with lenders, marketplaces and personal financial management platforms to provide real-time, verified consumer credit data to process payments as part of their clients’ existing workflow and operations via APIs and its agentic AI platform.
dataplor
dataplor provides point-of-interest (POI) data for businesses across the economy for geospatial analyses, operational workflows, and growth initiatives. The company’s data service is refreshed regularly with rigorous quality checks, and goes far beyond basic business names and addresses, enriching each location with brand, transaction, persona, foot-traffic estimates, hours of operation, sentiment scores, popularity metrics, and more, providing an unmatched combination of depth, breadth, and global coverage.
LeadIQ
LeadIQ is a workflow centric lead data and sales prospecting SaaS platform focused on enterprise and mid-market clients. LeadIQ allows users to research and capture potential leads easily, enrich leads with further details, and integrates into various sales acceleration and customer management platforms like Salesloft, Outreach, Hubspot and Salesforce.
An Eight Roads investment. Eight Roads is F-Prime’s sister venture capital investment group, with which F-Prime collaborates on investments outside of the Americas and Europe.
* Denotes activity with the non-F-Prime investment team.