Stephen Knight, M.D.

President & Managing Partner

617-231-2400

About

Stephen Knight joined F-Prime Capital in 2003 where he serves as President and Managing Partner. He has worked in the pharmaceutical and biotechnology industries for over 25 years and invests broadly across healthcare.  Steve serves on the Board of Directors of Beam Therapeutics (NASDAQ: BEAM), Geneception, Genomics plc, Iora Health, Pulmocide and Sana Biotechnology.  Steve previously served on the boards of several private and public health care companies including Blueprint Medicines (NASDAQ: BPMC), Denali Therapeutics (NASDAQ: DNLI), FoldRx Pharmaceuticals (acquired by Pfizer), Innovent Biologics (1801.HK), (Ironwood Pharmaceuticals (NASDAQ: IRWD), NextWave Pharmaceuticals (acquired by Pfizer), Proteostasis Therapeutics (NASDAQ: PTI), Respivert, Ltd (acquired by J&J) and Semma Therapeutics (acquired by Vertex).

Prior to joining F-Prime Capital, Steve held various senior management roles in private and public biotechnology and consulting companies. He also was a researcher at AT&T Bell Laboratories, the National Institutes of Health, and Yale University. He holds an M.D. from the Yale University School of Medicine, an M.B.A. from the Yale School of Organization and Management and received a B.S. in biology from Columbia University, graduating summa cum laude and Phi Beta Kappa.

  • Apellis Pharmaceuticals, Inc. (NASDAQ: APLS) is a clinical-stage biopharmaceutical company focused on the development of novel therapeutic compounds to treat disease through the inhibition of the complement system, at the level of C3, the central protein in the complement cascade. Learn more at www.apellis.com.

    • Category

      • Therapeutics
    • Status

      • Public
    • Location

      Crestwood, KY

    • Year Invested

      2017

    • Team

  • Beam Therapeutics (NASDAQ: BEAM) is pioneering the use of CRISPR base editing to develop precision genetic medicines that treat disease, one letter at a time. Learn more at www.beamtx.com.

  • Bikam Pharmaceuticals is a drug discovery company focused on developing novel therapies for diseases of the eye with exceptionally high unmet medical need. Bikam Pharmaceuticals was acquired by Shire.

     

    • Category

      • Therapeutics
    • Status

      • Acquired
    • Location

      Cambridge, MA

    • Year Invested

      2007

    • Team

  • BioPalette is a life science start up formed out of Kobe University developing base editing technology for a range of applications. Learn more at www.biopalette.co.jp.

  • Blueprint Medicines (NASDAQ: BPMC) is a precision therapy company striving to improve human health. Learn more at www.blueprintmedicines.com.

    • Category

      • Therapeutics
    • Status

      • Public
    • Location

      Cambridge, MA

    • Year Invested

      2012

    • Team

  • CardioKine is a pharmaceutical company focused on the development of lixivaptan, an oral compound under development for the potential treatment of hyponatremia in patients with congestive heart failure. CardioKine was acquired by Cornerstone Therapeutics.

  • Compass is comprehensively drugging the tumor-immune synapse with human antibodies against over 50 cell surface and soluble targets. Learn more at www.compasstherapeutics.com.

    • Category

      • Therapeutics
    • Status

      • Private
    • Location

      Cambridge, MA

    • Year Invested

      2015

    • Team

  • Denali Therapeutics (NASDAQ:DNLI) is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development. Learn more at www.denalitherapeutics.com.

  • FoldRx Pharmaceuticals focuses on creating disease modifying drug therapies for diseases of protein misfolding. FoldRx developed, tafamidis, the first-in-class therapy approved or TTR amyloidosis. FoldRx was acquired by Pfizer.

  • Genomics plc’s vision is to use genomic insights to transform the drug discovery industry by getting better drugs developed more quickly and targeted at the right group of patients. Learn more at https://www.genomicsplc.com

  • Hua Medicine (2552.KHK) is a leading clinical-stage, innovative drug development company in China, focused on novel therapies for the treatment of diabetes and CNS disorders. Learn more at www.huamedicine.com.

  • Innovent Biologics (1801.HK) has built a robust pipeline of innovative and commercially promising monoclonal antibodies and other biologics in the fields of oncology, ophthalmology, autoimmune, and cardiovascular diseases. Learn more at www.innoventbio.com.

  • Iora Health is building a different kind of health system to deliver high impact, relationship based care. Learn more at www.iorahealth.com.

  • Ironwood Pharmaceuticals (NASDAQ:IRWD) developed  linaclotide, a first-in-class therapy that received FDA approval for both irritable bowel syndrome and chronic constipation. Learn more at www.ironwoodpharma.com.

    • Category

      • Therapeutics
    • Status

      • Public
    • Location

      Cambridge, MA

    • Year Invested

      2002

    • Team

  • LigoCyte Pharmaceuticals was a vaccine discovery and development company with a first-in-class vaccine for norovirus, a pathogen that is a leading cause of viral gastroenteritis (stomach flu). LigoCyte Pharmaceuticals was acquired by Takeda.

    • Category

      • Therapeutics
    • Status

      • Acquired
    • Location

      Bozeman, MT

    • Year Invested

      2008

    • Team

  • LunaDNA is the first health and genomic data platform owned by its community of personal health information donors. LunaDNA empowers individuals to share their health data for medical research and the greater good of the community. As community owners in the LunaDNA platform, members share in the value created from health discoveries and medical breakthroughs. LunaDNA was created by the privately-owned Public Benefit Corporation, LunaPBC, founded in 2017 and headquartered in La Jolla, California. The LunaPBC team, investors, and advisors are renowned in the patient-advocacy, health, and science fields, including several former chief executives of Illumina, industry academics, and financial executives. Learn more at www.lunadna.com.

  • NextWave Pharmaceuticals is a specialty pharmaceutical company seeking to create and promote differentiated products in the pediatric market. NextWave Pharmaceuticals was acquired by Pfizer.

  • Orchard Therapeutics (NASDAQ:ORTX) Orchard Therapeutics is a fully integrated commercial-stage biopharmaceutical company dedicated to transforming the lives of patients with serious and life-threatening rare diseases through innovative gene therapies. Learn more at www.orchard-tx.com.

  • Proteostasis Therapeutics (NASDAQ: PTI)  is a drug discovery company developing small molecule therapeutics to treat cystic fibrosis and other diseases caused by dysfunctional protein processing. Learn more at www.proteostasis.com.

    • Category

      • Therapeutics
    • Status

      • Public
    • Location

      Cambridge, MA

    • Year Invested

      2008

    • Team

  • Pulmocide is a biopharmaceutical company with a mission to treat common acute and chronic respiratory tract infections associated with serious complications and devastating effects on patients’ quality of life. Learn more at www.pulmocide.com.

  • RespiVert was a drug discovery and development company focused on inhaled therapies for severe respiratory disease. RespiVert was acquired by Centocor Ortho Biotech – a division of Johnson & Johnson.

    • Category

      • Therapeutics
    • Status

      • Acquired
    • Location

      London, UK

    • Year Invested

      2007

    • Team

  • Sana Biotechnology, Inc. is focused on creating and delivering engineered cells as medicine for patients. We are a team of scientists, clinicians and biotechnology veterans focused on creating an enduring company that makes meaningful medicines and changes how we approach treating disease. Learn more about Sana at www.sana.com.

  • Semma Therapeutics is a regenerative medicine company founded to develop transformative stem cell-derived therapies to provide a functional cure for patients with diabetes. This company was acquired by Vertex in 2019.

  • TCT Medical is a diagnostic company based in China which provides high quality diagnostic tests, primarily in the women’s health arena. TCT Medical was acquired by Hologic.

    • Category

      • MedTech
    • Status

      • Acquired
    • Location

      Beijing, China

    • Year Invested

      2009

    • Team

  • Ultragenyx (NASDAQ: RARE) a biopharmaceutical company committed to bringing to patients novel products for the treatment of serious rare and ultra-rare genetic diseases. Learn more at www.ultragenyx.com.

    • Category

      • Therapeutics
    • Status

      • Public
    • Location

      Novato, CA

    • Year Invested

      2011

    • Team

  • Verve Therapeutics is a biotechnology company created with a singular focus: to protect the world from heart disease. Verve is developing therapies to safely edit the genome of adults and confer lifelong protection from coronary artery disease, the most common form of heart disease and the leading cause of death worldwide. Learn more at www.vervetx.com.