February 7, 2019

Innovent Receives IND Approval of a Bispecific Antibody (IBI318) by the NMPA

SUZHOU, ChinaFeb. 7, 2019 /PRNewswire/ — Innovent Biologics, Inc. (Innovent) (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high quality innovative medicines for the treatment of oncology, autoimmune and other major diseases, today announced that its IND application for IBI318, a recombinant fully human bispecific antibody targeting programmed cell death protein 1 (PD-1) and an undisclosed target for a tumor-associated antigen (TAA), recently has been approved by the National Medical Products Administration (NMPA) to initiate clinical trials in patients with hematological and advanced solid tumors.

PD-1 is a validated target in the field of anti-tumor immunotherapy. Anti-PD-1 monoclonal antibodies as single agents and in combination with chemotherapy have shown superior efficacy compared to the previous standard of care treatment in multiple tumor types, and have provided patients with new treatment options. However, monotherapy and combination therapy with anti-PD-1 antibodies in solid tumors only benefit a fraction of cancer patients. Development of more effective immunotherapies enables more cancer patients to benefit from this innovative therapeutic approach.

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