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June 12, 2018

Denali Therapeutics and AbCellera Announce Collaboration to Discover New Antibodies to Treat Neurodegenerative Diseases

VANCOUVER, British Columbia — AbCellera Biologics Inc. today announced the successful completion of the first phase of its collaboration with Denali Therapeutics Inc. (NASDAQ: DNLI). Under the collaboration, AbCellera applied its single-cell screening technology to discover hundreds of novel monoclonal antibodies with specific binding properties against a genetically-validated target for neurodegenerative disease.

Denali’s CEO, Ryan Watts, Ph.D., commented, “We are thrilled to collaborate with AbCellera to discover biologics candidates that leverage our proprietary Antibody Transport Vehicle (“ATV”) to cross the blood-brain barrier and that could ultimately benefit patients suffering from neurodegenerative diseases. We are impressed with the AbCellera team’s expertise and approach.”

AbCellera performs ultra-deep screening of natural immune repertoires from any species to discover antibodies from millions of single cells per run, including plasma cells, B-cells and antibody-secreting cells. AbCellera’s platform supports a wide array of single-cell antibody selection assays, combining multi-step and multiplexed binding measurements, and live-cell assays. The combination of speed, screening depth, and greater specificity generates thousands of high-quality antibodies, and translates to successful discovery against difficult targets such as membrane proteins, GPCRs and ion channels.

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