Blog

Iora Health Looks to ‘Kick the Industry in the Behind’

Boston-based Iora Health, the care team-oriented Medicare Advantage primary care provider, this month secured $100 million in funding to support its growth and technology platform.

Rushika Fernandopulle, MD, co-founder and CEO of Iora Health, spoke with HealthLeaders Media about the provider’s plans for expansion, and the care model that he believes can transform healthcare delivery.

The following is an edited transcript.

Fernandopulle: We obviously think we are unique, although increasingly the rest of the world is figuring out that we’re going in the right direction. We’re saying that if we want to change healthcare, then we have to change how actual people get actual care, not just nibbling around the edges. A good place to start is primary care.

The primary care model, which is take-a-number reactive and receive-a-service transactional, isn’t what we need. What we need is a radically different model that is relational. And that is what we are doing.

Read More

PatientPing Partners with WISHIN to Advance Care Coordination Throughout Wisconsin

MADISON, Wis. — The Wisconsin Statewide Health Information Network (WISHIN), Wisconsin’s designated entity for Health Information Exchange (HIE), is pleased to announce an innovative partnership with PatientPing, the nation’s leading care-coordination platform, to improve care coordination across hundreds of hospitals, clinics, post-acute care facilities, ACOs, health plans and other community health care organizations throughout Wisconsin.

Through this partnership, participating payers and providers will benefit from access to PatientPing’s real-time patient information– “Pings” and “Stories” –to better coordinate patient care. These notifications, from 1,500 sites of care in WISHIN’s statewide network, plus thousands more in PatientPing’s national network, offer payers and providers increased visibility into patient encounters outside their virtual four walls, and even across state lines. This advancement of care-coordination technology is especially valuable as providers become increasingly responsible for patient outcomes and as the federal government continues to push for increased interoperability across the care continuum.

Read More

Denali Therapeutics and AbCellera Announce Collaboration to Discover New Antibodies to Treat Neurodegenerative Diseases

VANCOUVER, British Columbia — AbCellera Biologics Inc. today announced the successful completion of the first phase of its collaboration with Denali Therapeutics Inc. (NASDAQ: DNLI). Under the collaboration, AbCellera applied its single-cell screening technology to discover hundreds of novel monoclonal antibodies with specific binding properties against a genetically-validated target for neurodegenerative disease.

Denali’s CEO, Ryan Watts, Ph.D., commented, “We are thrilled to collaborate with AbCellera to discover biologics candidates that leverage our proprietary Antibody Transport Vehicle (“ATV”) to cross the blood-brain barrier and that could ultimately benefit patients suffering from neurodegenerative diseases. We are impressed with the AbCellera team’s expertise and approach.”

AbCellera performs ultra-deep screening of natural immune repertoires from any species to discover antibodies from millions of single cells per run, including plasma cells, B-cells and antibody-secreting cells. AbCellera’s platform supports a wide array of single-cell antibody selection assays, combining multi-step and multiplexed binding measurements, and live-cell assays. The combination of speed, screening depth, and greater specificity generates thousands of high-quality antibodies, and translates to successful discovery against difficult targets such as membrane proteins, GPCRs and ion channels.

Read More

TraceLink Tracks Down $60M to Fight Counterfeit Drugs Worldwide

Xconomy Boston — A global proliferation of subpar and fake prescription drugs is driving more investment into businesses combating the problem with new software-based systems for tracking the supply chain of pharmaceuticals.

TraceLink is one of those companies on the rise, and the North Reading, MA-based firm recently raised $60 million in a new venture capital round, according to a document filed with the SEC. That brings TraceLink’s total equity funding to at least $137.2 million, per SEC filings. Its investors include Goldman Sachs, FirstMark Capital, Volition Capital, and F-Prime Capital. TraceLink officials couldn’t be immediately reached for comment Monday morning.

TraceLink sells cloud-based software that enables companies in the pharmaceutical industry to perform various tasks around authenticating and tracking the drugs they work with. That includes meeting regulatory compliance standards, storing what can be a massive amount of data created by tracking individual packages of drugs, and interacting with other companies that use TraceLink (such as manufacturers coordinating with distributors).

As Xconomy has reported, the nine-year-old company aims to not only let customers track large amounts of data, but its software is also meant to let them exchange data on the platform, almost like a social network, co-founder and CEO Shabbir Dahod said in a 2015 interview.

Read More

Hua Medicine Planning Hong Kong IPO

Diabetes company Hua Medicine Ltd. (Shanghai, China) filed for an IPO on the Hong Kong stock exchange underwritten by Goldman Sachs and CLSA Capital Markets.

Hua is the second biotech company to file for a Hong Kong listing since Hong Kong Exchanges and Clearing Ltd. (HKEX) opened a new prerevenue biotech chapter on April 30. Antiviral play Ascletis Pharma Inc. (Hangzhou, China) is also planning a listing, with Goldman Sachs among its underwriters (see BioCentury Extra, May 7).

Hua initially contemplated a U.S. IPO, but reconsidered based on the HKEX changes. EVP and CFO George Lin told BioCentury in January that Hua was aiming to raise $150 million in an IPO in 2H18. The company subsequently declined to comment on reports that it would seek $400 million in the listing (see BioCentury, Jan. 25).

Read more

TraceLink Customers Receive EMVO Approval for Data Submission to EU Hub

NORTH READING, Mass. — TraceLink Inc., the World’s Largest Track and Trace Network for connecting the life sciences supply chain and providing real-time information sharing for better patient outcomes, today announced that it has developed a streamlined program for its more than 190 customers to rapidly complete conformance testing and successfully receive European Medicines Verification Organization (EMVO) approval to submit data to the EU Hub – a complex and lengthy process that requires each individual company to complete EMVO registration and provide a full set of test cases to be executed for conformance with the EU Hub.
In just one month, 34 companies have completed their conformance testing with TraceLink’s conformance test kit. Of these, 11 companies have received EMVO approval to submit data to the EU Hub and 14 companies are awaiting review from the EMVO. In order to achieve final approval, all pharmaceutical companies must now submit a series of transactions to be reviewed by the EMVO, a process that can now take several weeks due to the surge of companies seeking to connect to the EU Hub before the EU Falsified Medicines Directive (FMD) deadline in February 2019. Once the transactions are approved by the EMVO, a pharmaceutical company will receive access to the certificates required for production and data submission to the EU Hub.

Read More

Adaptimmune Announces First Patient to Receive One Billion Target Cell Dose after Positive Safety Data from Pilot Study with MAGE-A4 SPEAR T-cells

PHILADELPHIA, Pa. and OXFORD, U.K. — Adaptimmune Therapeutics plc (Nasdaq:ADAP), a leader in T-cell therapy to treat cancer, today announced that the independent safety review committee has recommended dose escalation in the MAGE-A4 basket study, based on an acceptable safety profile in three patients dosed with 100 million cells. The company will start treating patients with the target dose of one billion transduced MAGE-A4 SPEAR T-cells in the ongoing basket study.

In addition, after confirming expression levels for MAGE-A4 from synovial sarcoma and myxoid/round cell liposarcoma (MRCLS) tumor samples, Adaptimmune has amended the study to add these two indications to the ongoing basket study, which already includes bladder, melanoma, head & neck, esophageal, gastric, ovarian, and non-small cell lung (NSCLC) cancers. Screening of patients with synovial sarcoma and MRCLS is ongoing.

“Today’s announcement that we are dosing patients with one billion cells, which we believe is a potentially therapeutic dose based on data from NY-ESO, means that we are on target to get response data in our MAGE-A4 study, to which we have added two solid tumor indications, in 2018,” said James Noble, Adaptimmune’s Chief Executive Officer. “This follows the earlier announcement that pilot studies in our other program, MAGE-A10, have also moved to the one billion cells dose.”

Read More

Circulation Teams Up with AI Powered Buoy Health to Bring On-Demand Transportation Options to Millions of Patients Online

Nationwide partnership solves for major issue in the industry by making it easy for consumers online to be transported to recommended care as soon as they realize something is wrong

BOSTON–(BUSINESS WIRE)–Circulation Health (www.circulation.com), a ride-ordering exchange that coordinates medical transportation logistics using Lyft and other transportation partners, today announced that it has entered into a nationwide partnership with Buoy Health (www.buoyhealth.com), to help millions of patients online receive the care they need when they need it the most. The partnership – which will roll out before the end of 2018 – will introduce Buoy’s patients to an even further streamlined, end-to-end healthcare experience by making it easy for them, post assessment, to book reliable on-demand transportation, powered by Circulation, to recommended care.

“Ultimately, it comes down to providing a better experience to individuals who need timely access to care,” said Robin Heffernan, CEO & Co-Founder of Circulation. “And since every patient journey starts with a ride, it makes so much sense to give Buoy users easy access to convenient, reliable transportation to their local pharmacies, primary care clinics, or urgent care centers.”

Read more

Navigant, Lumere Collaborate to Help Healthcare Providers Target Clinical and Financial Variation

Combination of analytics, research, and performance improvement expertise to support evidence-based medical device and drug selection, utilization

CHICAGO–(BUSINESS WIRE)–Navigant (NYSE: NCI) and Lumere today announced a collaboration to help healthcare providers implement evidence-based, technology-enabled consulting solutions aimed at reducing clinical and financial variation. The goal of the collaboration is to assist hospitals and health systems with reducing unnecessary utilization of drugs and medical devices in such areas as orthopedic, spine, cardiac, and surgical services.

Research suggests up to a quarter of overall healthcare expenditures are wasteful and not associated with improved quality. A proven way to reduce waste is to target unnecessary variation in clinical processes. However, providers often lack the resources to analyze major clinical cost factors necessary to drive action.

Read more

Turnstone Biologics listed in top 10 among Canada’s 50 most attractive VC companies

Innovative biotechnology firm BlueRock Therapeutics and Vancouver-based social media management firm Hootsuite are amongst those featured on the University of Toronto’s Narwhal 2018 rankings, listing the 50 most financially attractive technology companies within Canada.

The Impact Centre at the University of Toronto highlights the young firms and startups most likely to reach unicorn status on the list, having studied more than 1,000 private venture capital (VC) funded businesses.

Read more