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September 13, 2018

Innovent doses first patient in Phase III sintilimab trial for NSCLC

China-based biopharmaceutical company Innovent Biologics has dosed the first patient in the Phase III ORIENT-11 trial designed to evaluate sintilimab (IBI308) as first-line treatment for patients with non-squamous non-small cell lung cancer (NSCLC).

The randomised, double-blinded, multicentre trial intends to study sintilimab or placebo along with pemetrexed and platinum-based chemotherapy as first-line treatment to advanced or ns-NSCLC patients in China.

The trial is currently treating patients with the study drug combination in four cycles, followed by a maintenance treatment of sintilimab or placebo in combination with pemetrexed until the first occurrence of disease progression, intolerable toxicity, withdrawal of consent, death, or other specified events of the trial.

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